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Innovation in Transdermal Delivery of Drugs by Transfersomes

Authors: Soni

Published: 2025-02-17 01:04:31.445

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Abstract

Transdermal drug delivery offers distinct advantages over oral administration, such as bypassing the gastrointestinal tract and reducing systemic side effects. However, challenges like the delivery of large molecules and overcoming the stratum corneum barrier have limited its potential. Transfersomes, ultradeformable vesicles introduced in the early 1990s, present a promising solution to these issues. These elastic vesicles can squeeze through pores much smaller than their size, facilitating the transport of drugs across the skin. Composed of phospholipids and surfactants, transfersomes leverage osmotic forces and hydration to enhance permeation through the skin’s lipid layers. Their unique flexibility allows them to carry a wide range of molecules, including hydrophilic, lipophilic, and amphiphilic drugs. This versatility enables the delivery of both low and high molecular weight drugs such as analgesics, corticosteroids, insulin, anticancer agents, and even large proteins like albumin. In addition, transfersomes show promise in novel applications such as peripheral drug targeting and transdermal immunization. By improving the bioavailability of drugs and expanding therapeutic possibilities, transfersomes are poised to revolutionize drug delivery systems.

Keywords

Transdermal drug delivery, transfersomes, ultradeformable vesicles, skin permeability, drug targeting, immunization, drug carriers.

References

  1. Chein YW, Advance in Transdermal Systemic Medication. In: Ping IL and William RG (eds), Controlled Released Technology-Pharmaceutical Application, Washington DC: American Chemical Society, 1987, 98-109
  2. Chein YW, Chi SL, Transdermal Drug Delivery System with Enhanced skin Permeability, In: Ping IL and William RG (eds), Controlled Released Technology- Pharmaceutical Application, Washington DC: American Chemical Society, 1987, 81- 299
  3. Gamal M, Maghraby M, Williams AC, Barry BW, Skin Delivery of Oestradiol from Deformable and Traditional Liposomes- Mechanistic Studies, Journal of Pharmacy & Pharmacology, 51, 1999, 1123-1134
  4. Heather AE, Benson: Transdermal Drug Delivery:Penetration Enhancement Techniques, Current Drug Delivery, 2, 2005, 23-33
  5. Kumar P, Sankar C, and Mishra B, Delivery of macromolecules through skin, The Indian Pharmacist, 2004, 7-17. Misra AN, Transdermal Drug Delivery, In: N.K. Jain (eds.) Controlled and Novel Drug Delivery. New Delhi,CBS Publishers, 1997, 100-129
  6. Patel R, Singh SK, Singh S, Sheth NR, Gendle R, Development and Characterization of Curcumin Loaded Transfersomes for Transdermal Delivery, J. Pharm. Sci. & Res, 1(4), 2009, 71 80
  7. Paul G Cevc BK, Bachhawat, Transdermal immunization with large proteins by means of ultra deformable drug carriers, Eur. J. Immunol, 25, 1995, 35221–35224
  8. Roger Dmochowski R, Jonathan Starkman S, Willy Davila G, Transdermal Drug Delivery Treatment for Overactive Bladder, International Braz J Urol, (32)5, 2006, 513-520
  9. Schatzlein A and Cevc G. Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes). British Journal of Dermatology, 138, 1998, 583-598
  10. Schatzlein A and Cevc G: Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes). British Journal of Dermatology, 138, 1998, 583-598
  11. Vyas SP, Khar RK, Controlled drug delivery system, Pitampura, Delhi, Vallabh prakashan, 2005, 417-426
  12. Zhao, X., & Leong, L. (2020). "Evaluating Novel Testing Methods in Equipment Operation: A Case Study of Logging Machinery." Journal of Occupational Performance Assessment, 22(1), 77-89
  13. Almeida, J. M., & Batista, R. A. (2020). Transfersomes as a transdermal delivery system for drugs: Mechanisms and applications. Journal of Controlled Release, 324(2), 134-145. https://doi.org/10.1016/j.jconrel.2020.04.014
  14. Basha, M., & Sahu, S. (2021). Optimization of transfersomes for efficient drug delivery: Influence of formulation variables. International Journal of Pharmaceutics, 612, 121528
  15. https://doi.org/10.1016/j.ijpharm.2021.121528
  16. Cheng, X., & Zhang, Y. (2022). Structural dynamics of transfersomes and their role in enhancing transdermal drug penetration. Journal of Drug Delivery Science and Technology, 69, 103219. https://doi.org/10.1016/j.jddst.2022.103219
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How to Cite

Soni, (2025-02-17 01:04:31.445). Innovation in Transdermal Delivery of Drugs by Transfersomes. Abhi International Journal of Chemical and Pharmaceutical Science, Volume 6F6ruENJWxGRG765PVMf, Issue 1.

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