Abstract

The study is about the preparation and evaluation of bucoadhesive tablets containing Midazolam microspheres for buccal drug delivery. Focusing on site-specific drug delivery, it is to enhance bioavailability and minimize first-pass metabolism for quicker delivery to the brain. Five sub-questions have been critically addressed in the research: microsphere characteristics, bioadhesive strength, controlled drug release, drug-polymer interactions, and overall drug delivery efficiency. A quantitative methodology involves the assessment of independent variables such as polymer type and microsphere formulation against dependent variables like the rate of drug release and bioadhesive strength. Results show advancements in properties of microspheres, enhanced long-term bioadhesion, controlled drug release, chemical stability, and improved overall delivery efficiency. However, the results of this study indicate significant gaps regarding long-term data and have encouraged further work on varied polymer combinations along with the extension of outcome. This work adds to the development and improvement of bucoadhesive drug delivery systems; thus, it provides potential answers to optimize therapeutic applications.