Abstract

Vitamin B12, folic acid, and thyroid hormones' interaction is a critical relationship that is relevant to pregnancy, for the sake of both mothers and the babies. This article presents this association in pregnant women with subclinical hypothyroidism. Quantitative analysis was conducted on the 160 participants, differentiated between trimester and health status. Vitamin B12 and folic acid are independent variables, while FT3, FT4, and TSH are dependent variables. Results showed trimester-specific correlations that were significant; a positive correlation between Vitamin B12 and FT3 in healthy pregnancies, a negative association between Vitamin B12 and FT4 in subclinical hypothyroid pregnancies, and a negative correlation between cord blood Vitamin B12 and TSH. Findings emphasized the need for trimester-specific monitoring and supplementation of vitamins to maintain optimal thyroid function during pregnancy. However, limitations such as observational design and sample diversity call for longitudinal studies that would help establish causal relationships. Therefore, this research contributes toward understanding vitamin-hormone interactions, providing practical insight into the management of thyroid health in pregnancy.