Abstract

The purpose of this study is to ascertain the anthelmintic activities of seed oils produced from Ricinus communis, Brassica nigra, and Madhuca indica against Pheretima posthuma - the common model for assessing efficacy against these drugs. The measurement for paralysis and death time for the worms in the case of exposed oils was at different concentrations 10 mg/mL, 25 mg/mL, and 50 mg/mL. Comparative analysis with the synthetic anthelmintic reference standard, Piperazine citrate (10 mg/mL), underscores the potential of these natural oils as sustainable alternatives. Results indicate that higher concentrations of seed oils lead to faster paralysis and death of the worms, with activity levels varying across the oils tested. The study highlights the transition from synthetic to natural anthelmintics, emphasizing the environmental and health benefits of plant-derived compounds. While the results are encouraging, the study recognizes the requirement for further research into these oils to fully validate their efficacy and safety. This research contributes to developing sustainable, eco-friendly anthelmintic therapies