Abstract

Preeclampsia is a major hypertensive disorder in pregnancy that negatively alters maternal and fetal health outcomes. This study explored the role of G Protein-Coupled Receptors (GPCRs) in the preeclamptic placenta by examining their expression profiles and functional effects. Differential GPCRs expression between healthy and preeclamptic placentae is determined by RNA sequencing data, and further focused on adhesion and atypical chemokine receptors. Findings indicate that changes in GPCR expression have significant implications in placental functions such as trophoblast invasion, angiogenesis, and inflammatory responses. This offers hope for the development of therapies toward the improvement of the current management of preeclampsia. It represents a comprehensive analysis and shows necessity for further research in such pathways and therapeutic interventions in aspects of maternal-fetal health outcomes.