Evaluating the Cytotoxicity of 6-Mercaptopurine and Its Derivatives on Cancer Cells

Pramod Kumar Arya

Evaluating the Cytotoxicity of 6-Mercaptopurine and Its Derivatives on Cancer Cells

Authors: Pramod Kumar Arya

Published: 2025-01-07 18:17:43.109

Abstract

This research aims to find the cytotoxic effects of 6-Mercaptopurine (6-MP) and its derivatives, namely 6-Hydroxy-2-Mercaptopurine (6H2MP) and 2-Amino-9-butyl-6-Mercaptopurine (2A9B6-MP), on HepG2 and MCF-7 cancer cell lines. It utilizes quantitative methods to research cell viability via MTT assays at different concentrations of these compounds. The outcome showed that 6-MP has strong cytotoxicity on HepG2 cells, with MCF-7 being more resistant. Comparison studies suggested that 6-MP was more potent than its derivatives. The results have underlined the potential use of 6-MP in the treatment of liver cancer and point to a need for further research in molecular mechanisms and in vivo validations.

Keywords

Cytotoxicity, Cancer treatment, Chemotherapy, 6H2MP

References

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How to Cite

Pramod Kumar Arya, (2025-01-07 18:17:43.109). Evaluating the Cytotoxicity of 6-Mercaptopurine and Its Derivatives on Cancer Cells. Abhi International Journal of Biological Science, Volume shei9IKj93kNVodFcGtA, Issue 1.

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Abhi International Journal of
Biological Science ( AIJBS )